Welcome to MMpI
MMpI is a unique resource that contains detailed information on the MMP inhibitors inclusion small molecules and peptides and comprehensive list of MMP drug leads. The database contains 3000 inhibitors entries including 72 MMP drug leads and 73 peptide based inhibitors. MMpI is primarily engrossed on providing the detailed molecular and structural data needed to enable drug discovery and drug development.
The importance of matrix metalloprotease (MMP) in degradation of collagen and its relevance to arthritis and cancer have been well established. Therefore several attempts have been made to develop inhibitors for MMPs. However, there is no suitable database regarding the inhibitors for various MMPs. In this project, an attempt has been collect details about various inhibitors from previous studies to develop a comprehensive database.
Matrix metalloproteinases (MMPs) are a large family of calcium-dependent zinc-containing endopeptidases, which are responsible for the tissue remodeling and degradation of the extracellular matrix (ECM), including collagens, elastins, gelatin, matrix glycoproteins, and proteoglycan. They are regulated by hormones, growth factors, and cytokines, and are involved in ovarian functions.
The authors wish to thank the Council of Scientific and Industrial Research (CSIR), Department of Biotechnology (DBT) and GENESIS project New Delhi, India, for financial support.